Protocol
Anti-Aging Longevity
Multi-axis longevity protocol targeting pineal, mitochondrial, and dermal aging.
Why this stack
The rationale.
The three peptides hit three independent aging axes: Epitalon is a tetrapeptide that activates telomerase and resets pineal melatonin production, MOTS-c is a mitochondrial-derived peptide that improves insulin sensitivity and AMPK signaling, and low-dose GHK-Cu maintains the dermal and gene-regulatory background. Pulsing Epitalon rather than running it continuously matches the original Khavinson protocols and avoids unknown long-term telomerase signaling, while MOTS-c and GHK-Cu provide the steady-state coverage between pulses. This is an advanced stack because three peptides means three attribution problems if something goes wrong — only run it after simpler protocols have already established personal baseline.
The protocol
Dose, frequency, cycle.
- Dose
- 10,000mcg
- Frequency
- Daily
- Cycle
- 2 weeks on, 12 weeks off
- Timing
- subq morning, two 10-day pulses (days 1-10 and days 100-110)
- Dose
- 5,000mcg
- Frequency
- 3×/week
- Cycle
- 12 weeks on, 8 weeks off
- Timing
- subq morning, MWF, pre-training on lifting days when possible
- Dose
- 1,000mcg
- Frequency
- 3×/week
- Cycle
- 20 weeks on, 8 weeks off
- Timing
- subq evening, MWF, low-dose continuous background
Expected timeline
What to expect, when.
weeks 1-2 (Epitalon pulse 1): sleep depth and dream vividness increase, melatonin rhythm normalizes. weeks 3-8: MOTS-c metabolic effects emerge — better fasted training tolerance, modest body-comp shift. weeks 8-14: skin and connective tissue gains from GHK-Cu plateau is reached, lab markers should improve. weeks 14-16 (Epitalon pulse 2): second pineal reset, often the most subjectively noticeable cycle phase. weeks 17-20: consolidate; long off-period after to let the HPA and pineal axes recalibrate before any repeat.
Monitoring markers
What to track.
- fasting glucose and insulin (HOMA-IR)
- HbA1c
- lipid panel including ApoB
- hsCRP
- IGF-1 (Epitalon can modulate the GH axis indirectly)
- DHEA-S and morning cortisol
- VO2 max if testable, otherwise resting HR and HRV trends
- epigenetic age test if available (baseline and post-protocol)
Contraindications
- active malignancy of any kind (telomerase and mitochondrial signaling implications)
- pregnancy or breastfeeding
- Wilson's disease (copper accumulation risk with GHK-Cu)
- active autoimmune flare
- uncontrolled metabolic disease — stabilize first
Description
Protocol overview.
Three peptides at three different cadences, each addressing a distinct aging axis. Epitalon runs in two short pulses for telomerase and pineal/melatonin reset, MOTS-c covers mitochondrial signaling and metabolic flexibility, low-dose GHK-Cu provides background dermal and gene-regulatory support. Designed for users who have already cycled simpler stacks.
Clone this protocol to your account.
Drop it onto your dashboard, pin doses to your weekly schedule, and let the daily-protocol screen tell you what to draw each morning. Reconstitution math, site rotation, and lab reminders come with it.