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LongevitySubcutaneous

MOTS-c

Also known as: Mitochondrial open reading frame of 12S rRNA-c

16-amino-acid mitochondrial-derived peptide encoded within the 12S rRNA region of mtDNA. Activates AMPK signaling, promotes glucose uptake, improves insulin sensitivity, and enhances mitochondrial biogenesis.

At a glance

Half-life
3 hours
Common route
Subcutaneous
Typical dose range
5,000–10,000mcg
Stability (reconstituted)
30days refrigerated

Best timing

Typically 3x weekly or daily for 10-day cycles. Pre-workout dosing aligns with exercise-mimetic effect.

Contraindications

  • Pregnancy
  • Type 1 diabetes (hypoglycemia risk)
  • Concurrent metformin or other AMPK activators without medical oversight

Watch symptoms

  • Hypoglycemic symptoms (rare)
  • Injection site reactions
  • Mild fatigue early in protocol
  • Limited long-term human data

Citations

The primary literature.

  1. 01The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistancePubMed
  2. 02MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasisPubMed

Related protocols

Stacks that use MOTS-c.

Anti-Aging Longevity

Multi-axis longevity protocol targeting pineal, mitochondrial, and dermal aging.

View protocol
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