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LongevitySubcutaneous

Epitalon

Also known as: Epithalon · Epithalamin tetrapeptide · Ala-Glu-Asp-Gly

Synthetic tetrapeptide derived from pineal gland extract. Upregulates telomerase activity in human somatic cells, extends telomere length in vitro, and normalizes melatonin rhythm in aging adults in Russian trials.

At a glance

Half-life
1 hours
Common route
Subcutaneous
Typical dose range
5,000–10,000mcg
Stability (reconstituted)
14days refrigerated

Best timing

Cycled — typical protocol is 10 days on, then off for 3–6 months. Often dosed pre-bed to align with pineal activity.

Contraindications

  • Active cancer (telomerase activation is theoretically pro-proliferative)
  • Pregnancy
  • Pediatric use

Watch symptoms

  • Vivid dreams
  • Mild sedation
  • Headache
  • Limited modern human safety data — most trials are Russian-language

Citations

The primary literature.

  1. 01Peptide Epitalon activates chromatin at the old age in human lymphocytesPubMed
  2. 02Inhibition of development of spontaneous mammary tumors in female mice of high-cancer-risk strain by EpitalonPubMed

Related protocols

Stacks that use Epitalon.

Anti-Aging Longevity

Multi-axis longevity protocol targeting pineal, mitochondrial, and dermal aging.

View protocol
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