Protocol
GLP-1 Starter
Twelve-week semaglutide titration for first-time GLP-1 users.
Why this stack
The rationale.
Semaglutide alone is the right answer for a first GLP-1 cycle. Stacking another peptide on top during the titration window confounds tolerability signals and makes side-effect attribution impossible. The job here is to establish baseline GI tolerance and a stable weekly dose before anything else is layered in.
The protocol
Dose, frequency, cycle.
- Dose
- 250mcg
- Frequency
- 1×/week
- Cycle
- 12 weeks on, continuous
- Timing
- same day each week, evening with light food to blunt nausea
Expected timeline
What to expect, when.
weeks 1-2: appetite shift, mild nausea on dose day. weeks 3-6: clear reduction in food noise, 1-3 lb loss. weeks 7-12: visible body composition change at the higher titrated doses, plateau check at week 10.
Monitoring markers
What to track.
- fasting glucose
- HbA1c
- fasting insulin
- resting heart rate
- weight (weekly, same time)
- waist circumference (biweekly)
Contraindications
- personal or family history of medullary thyroid carcinoma
- MEN2 syndrome
- active pancreatitis or prior pancreatitis
- pregnancy or active attempt to conceive
- severe gastroparesis
Description
Protocol overview.
A textbook semaglutide ramp built around tolerability rather than speed. Doses follow the standard four-week step pattern so the gut adapts before the appetite-suppression effect deepens. Single weekly injection, no stack, intentionally boring.
Clone this protocol to your account.
Drop it onto your dashboard, pin doses to your weekly schedule, and let the daily-protocol screen tell you what to draw each morning. Reconstitution math, site rotation, and lab reminders come with it.