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ImmuneSubcutaneous

Thymopentin (TP-5)

Also known as: TP-5 · Timopentin · Arg-Lys-Asp-Val-Tyr

Pentapeptide corresponding to residues 32–36 of thymopoietin. Promotes T-cell differentiation and maturation, modulates Th1/Th2 balance, and is approved in several countries as adjunctive therapy for hepatitis B and chronic viral infections.

At a glance

Half-life
30 minutes
Common route
Subcutaneous
Typical dose range
1,000–50,000mcg
Stability (reconstituted)
30days refrigerated

Best timing

Typically 3x weekly. Trial protocols use 50 mg subq three times weekly for chronic viral infection adjunct.

Contraindications

  • Active autoimmune disease without supervision
  • Pregnancy
  • Organ transplant on immunosuppression

Watch symptoms

  • Injection site reactions
  • Mild flu-like feeling early in protocol
  • Fatigue
  • Rare hypersensitivity reactions

Citations

The primary literature.

  1. 01Thymopentin: a review of its biological activity and clinical efficacyPubMed
  2. 02Thymopentin in immunodeficiency and autoimmune diseasePubMed
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