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LongevityIntramuscular
Thymalin
Also known as: Thymic extract peptide · Vilon precursor
Polypeptide complex extracted from calf thymus, developed by the Khavinson lab in Russia. Restores age-related decline in T-cell function and is associated with lower mortality in long-term Russian geriatric cohorts. Mechanism likely involves epigenetic regulation of immune gene expression.
At a glance
- Half-life
- 1 hours
- Common route
- Intramuscular
- Typical dose range
- 5,000–20,000mcg
- Stability (reconstituted)
- 14days refrigerated
Best timing
Daily IM for 10-day courses, then off. Khavinson protocols repeat 1–2x per year for geriatric immune support.
Contraindications
- Active autoimmune disease without supervision
- Pregnancy
- Organ transplant on immunosuppression
- Limited modern Western trial data — most research is Russian-language
Watch symptoms
- Mild injection site reactions
- Fatigue or flu-like feeling early in protocol
- Possible autoimmune symptom changes in susceptible individuals
- Sparse long-term safety data outside Russian-population studies
Citations