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LongevitySubcutaneous
SS-31 (Elamipretide)
Also known as: Elamipretide · MTP-131 · Bendavia
Cell-permeable tetrapeptide that selectively binds cardiolipin in the inner mitochondrial membrane. Stabilizes cristae structure, preserves electron transport chain efficiency, and reduces reactive oxygen species generation in damaged mitochondria.
At a glance
- Half-life
- 2 hours
- Common route
- Subcutaneous
- Typical dose range
- 1,000–40,000mcg
- Stability (reconstituted)
- 14days refrigerated
Best timing
Daily subq, typically AM. Clinical trials use 40 mg daily for mitochondrial myopathy; lower research doses are common in healthy populations.
Contraindications
- Pregnancy
- Known hypersensitivity
- Limited long-term data outside Phase 2/3 mitochondrial-disease trials
Watch symptoms
- Injection site reactions (most common)
- Mild fatigue or headache during first week
- Limited adverse-event signal in trials at standard doses
- Did not meet primary endpoints in heart failure (EMBRACE) and dry AMD trials — efficacy in healthy users is unproven
Citations