Agonist
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AestheticSubcutaneous

SNAP-8

Also known as: Acetyl Octapeptide-3 · Ac-EEMQRRADQ-NH2

Octapeptide extension of Argireline. Adds two additional amino acids to the SNAP-25 mimetic sequence — manufacturer data claim a stronger inhibition of SNARE complex formation and deeper wrinkle reduction than Argireline at equivalent concentrations.

At a glance

Half-life
4 hours
Common route
Subcutaneous
Typical dose range
1,000–5,000mcg
Stability (reconstituted)
30days refrigerated

Best timing

Topical serum twice daily for 4–8 weeks. Most evidence comes from manufacturer-funded studies — independent replication is sparse.

Contraindications

  • Pregnancy
  • Concurrent neuromuscular disease
  • Open wounds or active dermatitis at application site

Watch symptoms

  • Mild local irritation
  • Limited independent efficacy data
  • Concentration-dependent skin barrier effects

Citations

The primary literature.

  1. 01Anti-aging cosmeceutical peptides: ingredients, mechanisms, and trialsPubMed
  2. 02Peptides in cosmetics: a review of anti-wrinkle, brightening, and barrier-restoring sequencesPubMed
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