CognitiveIntranasal

Semax

Also known as: ACTH(4-10) Pro-Gly-Pro · Russian Semax

Heptapeptide analog of ACTH(4-10) lacking corticotropic activity. Increases BDNF and NGF expression in hippocampus, modulates dopamine and serotonin turnover, and has been used in Russian stroke protocols.

At a glance

Half-life: 30 minutes
Common route: Intranasal
Typical dose range: 300–1,500mcg
Stability (reconstituted): 21days refrigerated

Best timing

Intranasal, 1–3x daily. Avoid late evening — can be activating and disrupt sleep.

Contraindications

Pregnancy
Severe anxiety disorder (can be activating)
Acute psychiatric crisis

Watch symptoms

Overstimulation, restlessness
Insomnia if dosed late
Mild nasal irritation
Headache
Initial mood lift that flattens with daily use

Citations

The primary literature.

01Semax, an analogue of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampusPubMed
02Effects of heptapeptide Semax on learning and memory: behavioural, pharmacological and gene expression studiesPubMed

Related protocols

Stacks that use Semax.

Cognitive Edge

Eight-week Semax-Selank rotation for focus, mood, and cognitive resilience.

View protocol

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