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CognitiveSubcutaneous
NGF
Also known as: Nerve Growth Factor · Cenegermin · Oxervate
118-amino-acid neurotrophin essential for survival and growth of sympathetic and sensory neurons. Binds TrkA and p75NTR receptors to drive neurite outgrowth, neuronal survival, and corneal nerve regeneration. FDA-approved as cenegermin (Oxervate) eye drops for neurotrophic keratitis.
At a glance
- Half-life
- 4 hours
- Common route
- Subcutaneous
- Typical dose range
- 5–50mcg
- Stability (reconstituted)
- 14days refrigerated
Best timing
Approved route is ophthalmic drop. Systemic injection in research causes significant pain at injection site — generally avoided outside specialized protocols.
Contraindications
- Pregnancy
- Chronic pain syndromes (NGF is a key pain-signaling factor)
- Active cancer
- Hypersensitivity
Watch symptoms
- Severe injection site pain — NGF directly sensitizes nociceptors
- Hyperalgesia (whole-body pain hypersensitivity for hours-days)
- Inflammation at site
- Ocular irritation with topical use
Citations