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MetabolicSubcutaneous
NAD+
Also known as: Nicotinamide adenine dinucleotide · NAD
Essential coenzyme in redox reactions and substrate for sirtuins, PARPs, and CD38. Declines with age; supplementation restores cellular NAD+ pools, supporting mitochondrial function, DNA repair, and sirtuin-mediated longevity pathways.
At a glance
- Half-life
- 1 hours
- Common route
- Subcutaneous
- Typical dose range
- 50,000–500,000mcg
- Stability (reconstituted)
- 7days refrigerated
Best timing
Subq or IV. Slow administration essential — fast infusion causes intense chest pressure and nausea. Daily or 3x weekly protocols common.
Contraindications
- Pregnancy
- Active cancer (controversial — sirtuin and PARP activation may protect tumor cells)
- Severe cardiovascular disease (chest pressure during infusion)
Watch symptoms
- Chest pressure or tightness during/after dose (slow the dose)
- Nausea, flushing
- Headache
- Increased anxiety in some users
- Injection site soreness — burning is common
Citations