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CognitiveIntranasal

N-Acetyl Semax Amidate

Also known as: NA-Semax-Amidate · Acetyl-Semax-Amidate · NAS-Amidate

Stabilized analog of Semax with N-terminal acetylation and C-terminal amidation. Both modifications protect against enzymatic degradation, extending duration. Same heptapeptide ACTH(4-10) backbone — increases BDNF and modulates dopamine/serotonin turnover.

At a glance

Half-life
1 hours
Common route
Intranasal
Typical dose range
300–1,500mcg
Stability (reconstituted)
30days refrigerated

Best timing

Intranasal, 1–2x daily — typically requires lower frequency than plain Semax. Avoid late evening due to activating profile.

Contraindications

  • Pregnancy
  • Severe anxiety disorder (activating)
  • Acute psychiatric crisis
  • Limited human trial data outside basic Semax research

Watch symptoms

  • Overstimulation, restlessness
  • Insomnia if dosed late
  • Nasal irritation
  • Headache
  • Mood lift that may flatten with continuous daily use

Citations

The primary literature.

  1. 01Semax, an analogue of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampusPubMed
  2. 02Heptapeptide Semax and its effects on learning and memoryPubMed
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