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LongevitySubcutaneous
L-Carnosine
Also known as: Carnosine · beta-alanyl-L-histidine
Endogenous dipeptide (beta-alanine + histidine) concentrated in skeletal muscle and brain. Buffers intramuscular hydrogen ions during high-intensity work, chelates divalent metals (zinc, copper, iron) implicated in oxidative damage, and inhibits non-enzymatic glycation of proteins — a primary driver of advanced glycation end-product (AGE) accumulation in aging tissue.
At a glance
- Half-life
- 30 minutes
- Common route
- Subcutaneous
- Typical dose range
- 100,000–1,000,000mcg
- Stability (reconstituted)
- 30days refrigerated
Best timing
Daily, AM or split AM/PM. Oral doses are partially hydrolyzed to beta-alanine by serum carnosinase; injectable routes deliver intact dipeptide. Combine with zinc for chelation-related applications.
Contraindications
- Pregnancy and breastfeeding (insufficient data)
- Concurrent ACE inhibitors (theoretical histidine interaction; clinically minor)
Watch symptoms
- Paraesthesia (beta-alanine flush) at high doses
- Transient fatigue in first week of dosing
- Hypotension at IV bolus rates
Citations