Agonist
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HealingOral

KPV

Also known as: Lysine-Proline-Valine · α-MSH 11–13

C-terminal tripeptide of alpha-MSH. Inhibits NF-κB signaling and downregulates pro-inflammatory cytokines (IL-1β, TNF-α, IL-6). Used orally and topically for gut and skin inflammation.

At a glance

Half-life
2 hours
Common route
Oral
Typical dose range
200–1,000mcg
Stability (reconstituted)
30days refrigerated

Best timing

Oral capsule or sublingual, once or twice daily. Subq routes used for systemic inflammation protocols.

Contraindications

  • Known hypersensitivity
  • Pregnancy (no human data)
  • Active autoimmune flare without practitioner oversight

Watch symptoms

  • Mild GI changes
  • Headache
  • Fatigue early in protocol
  • Injection site irritation if used subq

Citations

The primary literature.

  1. 01Mechanism of action of the antimicrobial peptide KPV: comparison with melanocortin signalingPubMed
  2. 02The tripeptide KPV reduces inflammation in experimental colitisPubMed
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