Agonist
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AestheticSubcutaneous

Kisspeptin-54

Also known as: KP-54 · Metastin

Full-length 54-amino-acid form of kisspeptin, the upstream regulator of hypothalamic GnRH neurons. Activates KISS1R receptors to trigger LH and FSH release. Longer-acting than kisspeptin-10 — used in fertility trials and IVF triggering protocols.

At a glance

Half-life
30 minutes
Common route
Subcutaneous
Typical dose range
1,000–10,000mcg
Stability (reconstituted)
14days refrigerated

Best timing

Trial protocols use single or few injections rather than daily dosing — often as an IVF ovulation trigger or single-dose hypogonadism stimulation test.

Contraindications

  • Hormone-sensitive cancer
  • Pregnancy outside fertility protocols
  • Concurrent GnRH antagonist therapy
  • Limited long-term safety data

Watch symptoms

  • Injection site reactions
  • Headache
  • Theoretical OHSS risk in IVF use
  • Mood or libido fluctuations

Citations

The primary literature.

  1. 01Kisspeptin-54 triggers oocyte maturation in IVF in women at high risk of ovarian hyperstimulationPubMed
  2. 02Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human malesPubMed
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