Agonist
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AestheticSubcutaneous

Kisspeptin-10

Also known as: KP-10 · Metastin 45-54

Decapeptide fragment of kisspeptin-54. Acts at the KISS1R receptor on hypothalamic GnRH neurons to trigger downstream LH/FSH release. Considered an upstream regulator of the HPG axis and a promising fertility and hypogonadism target.

At a glance

Half-life
30 minutes
Common route
Subcutaneous
Typical dose range
50–500mcg
Stability (reconstituted)
14days refrigerated

Best timing

Pulsatile dosing in research protocols. Short half-life means multiple daily doses are required for sustained axis stimulation.

Contraindications

  • Hormone-sensitive cancers
  • Pregnancy
  • Concurrent GnRH antagonist therapy
  • Limited long-term safety data

Watch symptoms

  • Injection site reactions
  • Headache
  • Theoretical HPG axis effects with chronic high-dose use
  • Mood or libido changes

Citations

The primary literature.

  1. 01Kisspeptin-10 stimulates gonadotropin secretion in healthy men and womenPubMed
  2. 02Kisspeptin and the regulation of human reproductionPubMed
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