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LongevitySubcutaneous

Humanin

Also known as: HN · [Gly14]-Humanin · HNG

24-amino-acid mitochondrial-derived peptide with cytoprotective activity. Inhibits Bax-mediated apoptosis, protects against beta-amyloid toxicity, and declines with age — circulating levels inversely correlate with longevity markers.

At a glance

Half-life
2 hours
Common route
Subcutaneous
Typical dose range
250–1,000mcg
Stability (reconstituted)
30days refrigerated

Best timing

Daily or alternate-day dosing. Most users target 3–4 week cycles with break periods.

Contraindications

  • Pregnancy
  • Active cancer (anti-apoptotic activity may protect tumor cells)
  • Limited human data — practitioner oversight recommended

Watch symptoms

  • Few reported effects in research settings
  • Injection site reactions
  • Fatigue or sleep changes
  • Long-term safety data sparse

Citations

The primary literature.

  1. 01Humanin: a harbinger of mitochondrial-derived peptides?PubMed
  2. 02Humanin, a cytoprotective peptide, is expressed in carotid atherosclerotic plaques in humans and improves endothelial function in micePubMed
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