Agonist
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GH SecretagogueSubcutaneous

Hexarelin

Also known as: Examorelin · EP-23905

Synthetic hexapeptide ghrelin receptor agonist with the strongest GH pulse of the GHRP family. Also acts at CD36 receptors in cardiac tissue — animal data suggest direct cardioprotective effects independent of GH.

At a glance

Half-life
42 minutes
Common route
Subcutaneous
Typical dose range
100–200mcg
Stability (reconstituted)
30days refrigerated

Best timing

Fasted, 1–2x daily. Receptor desensitization develops within 2–4 weeks of daily use — cycle 4 weeks on, 4 weeks off.

Contraindications

  • Active cancer
  • Pituitary disease
  • Pregnancy
  • Diabetic retinopathy
  • Severe insulin resistance

Watch symptoms

  • Cortisol and prolactin elevation (more than GHRP-2)
  • Hunger increase
  • Tachyphylaxis — diminishing GH response over weeks
  • Water retention
  • Mild headache

Citations

The primary literature.

  1. 01Hexarelin, a synthetic GH-releasing peptide, induces a strong stimulation of GH secretion in normal subjectsPubMed
  2. 02Cardiovascular effects of hexarelin in humansPubMed
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