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MetabolicSubcutaneous
HCG
Also known as: Human Chorionic Gonadotropin · Pregnyl · Novarel
Glycoprotein hormone normally produced by the placenta. Structurally similar to LH and binds the LH/CG receptor on Leydig cells to drive testosterone production. Used to maintain testicular function during exogenous androgen therapy and in male fertility protocols.
At a glance
- Half-life
- 33 hours
- Common route
- Subcutaneous
- Typical dose range
- 250–5,000mcg
- Stability (reconstituted)
- 60days refrigerated
Best timing
Typically 2–3x weekly. Dosing in IU (typically 250–500 IU per dose for fertility/testicular preservation). 1 IU ≈ 1 mcg by convention for HCG dose calculations.
Contraindications
- Prostate or other androgen-sensitive cancer
- Precocious puberty
- Pregnancy
- Hypersensitivity to HCG or urinary-derived gonadotropins
Watch symptoms
- Estradiol elevation — possible gynecomastia, water retention
- Mood changes, irritability
- Acne, oily skin
- Headache
- Testicular discomfort early in protocol
Citations