Agonist
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GH SecretagogueSubcutaneous

GHRP-6

Also known as: Growth Hormone Releasing Peptide 6 · His-D-Trp-Ala-Trp-D-Phe-Lys-NH2

First-generation hexapeptide ghrelin receptor agonist. Produces strong GH release and pronounced appetite stimulation. Older than ipamorelin and GHRP-2 with a less clean profile — more prolactin, cortisol, and hunger.

At a glance

Half-life
30 minutes
Common route
Subcutaneous
Typical dose range
100–300mcg
Stability (reconstituted)
30days refrigerated

Best timing

Fasted, 2–3x daily. Hunger surge is steep — many users dose 30–45 minutes before a planned meal.

Contraindications

  • Active cancer
  • Pituitary disease
  • Pregnancy
  • Active eating disorder (intense hunger stimulation)
  • Cushing's syndrome

Watch symptoms

  • Intense hunger within 15–30 minutes of injection
  • Cortisol and prolactin elevation
  • Water retention
  • Fatigue or lethargy post-dose
  • Headache

Citations

The primary literature.

  1. 01GHRP-6 stimulates GH secretion and induces a positive nitrogen balance in healthy elderly subjectsPubMed
  2. 02Ghrelin and GHRP-6 protect the heart from ischemic injuryPubMed
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