Agonist
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GH SecretagogueSubcutaneous

GHRP-2

Also known as: Pralmorelin · KP-102 · Growth Hormone Releasing Peptide 2

Synthetic hexapeptide ghrelin receptor agonist. Produces a stronger GH pulse than ipamorelin but with measurable rises in prolactin, cortisol, and ACTH. Approved in Japan (as pralmorelin) for diagnostic GH stimulation testing.

At a glance

Half-life
30 minutes
Common route
Subcutaneous
Typical dose range
100–300mcg
Stability (reconstituted)
30days refrigerated

Best timing

Fasted state. 1–3x daily; often paired with a GHRH analog like CJC-1295 no-DAC for synergistic release.

Contraindications

  • Active cancer
  • Pituitary disease
  • Pregnancy
  • Cushing's or hypercortisolism (additional cortisol elevation)

Watch symptoms

  • Increased hunger (potent ghrelin agonism)
  • Cortisol-related symptoms — fluid retention, mood
  • Mild prolactin elevation — possible breast tenderness
  • Facial flushing
  • Numbness in hands (carpal tunnel)

Citations

The primary literature.

  1. 01Pralmorelin (GHRP-2) for diagnosis of severe adult GH deficiencyPubMed
  2. 02GHRP-2 increases growth hormone secretion in healthy older menPubMed
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