Agonist
Back to library
AestheticSubcutaneous

GHK-Cu (Cosmetic)

Also known as: Copper Peptide topical · GHK-Cu serum

Same tripeptide-copper complex used in healing protocols, applied topically or microneedled for skin remodeling. Stimulates fibroblast collagen and elastin synthesis, reduces wrinkle depth, and improves skin elasticity in human trials.

At a glance

Half-life
30 minutes
Common route
Subcutaneous
Typical dose range
100–1,000mcg
Stability (reconstituted)
14days refrigerated

Best timing

Topical serum 1–2x daily, or microneedling protocol every 2–4 weeks. Lower doses than systemic healing protocols.

Contraindications

  • Active rosacea flare or open wounds
  • Vitamin C application within 30 minutes (oxidative interaction)
  • Wilson's disease
  • Pregnancy

Watch symptoms

  • Bluish tint to skin if concentration is excessive
  • Mild irritation in sensitive skin
  • Increased photosensitivity
  • Hyperpigmentation in melanin-rich skin types

Citations

The primary literature.

  1. 01The human tri-peptide GHK and tissue remodelingPubMed
  2. 02Reparative and protective actions of selected biological peptides on skin (GHK-Cu)PubMed
Back to library