Agonist
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CognitiveOral

Dihexa

Also known as: N-hexanoic-Tyr-Ile-(6) aminohexanoic amide · PNB-0408

Orally bioavailable angiotensin IV analog. Potent hepatocyte growth factor (HGF) / c-Met receptor activator that promotes synaptogenesis. Pre-clinical data show enhanced dendritic spine formation in hippocampus.

At a glance

Half-life
10 hours
Common route
Oral
Typical dose range
8,000–45,000mcg
Stability (reconstituted)
30days refrigerated

Best timing

Oral, once daily with or without food. Effect on synaptic density is cumulative over weeks.

Contraindications

  • Active cancer (HGF/c-Met activation is mitogenic)
  • Pregnancy
  • Uncontrolled hypertension (angiotensin axis)

Watch symptoms

  • Headache
  • Overstimulation if stacked with other nootropics
  • Sleep disturbance
  • Limited human safety data — long-term effects unknown

Citations

The primary literature.

  1. 01A small molecule HGF mimetic (Dihexa) for the treatment of Alzheimer's diseasePubMed
  2. 02Identification of an angiotensin IV-derived small molecule (Dihexa) with procognitive activityPubMed
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