Agonist
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GH SecretagogueSubcutaneous

CJC-1295 (DAC)

Also known as: CJC with DAC · DAC:GRF · Long-acting CJC

GHRH analog with maleimidopropionic acid linker that binds covalently to serum albumin, extending half-life from minutes to ~8 days. Produces a sustained elevation of GH and IGF-1 rather than discrete pulses.

At a glance

Half-life
8 days
Common route
Subcutaneous
Typical dose range
1,000–2,000mcg
Stability (reconstituted)
30days refrigerated

Best timing

Once or twice weekly. Time-of-day not critical due to long half-life — many users dose Sunday evening.

Contraindications

  • Active cancer
  • Severe insulin resistance or unmanaged diabetes
  • Pregnancy
  • Diabetic retinopathy
  • Sleep apnea (untreated)

Watch symptoms

  • Sustained water retention (more than no-DAC variant)
  • Carpal tunnel symptoms
  • Mild insulin resistance over time
  • Joint achiness in first 2 weeks
  • Facial flushing on dose day

Citations

The primary literature.

  1. 01Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adultsPubMed
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